GERA’s investigator team has access to and experience using a number of valuable datasets and cohorts that can be utilised to enable and support genetic epidemiology research. Browse these resources below (click to read more).
Go back to: Data resources led by GERA investigators
Resources GERA investigators have experience with
45 and Up Study. Australia’s largest ongoing study of health and ageing: a population-based cohort including >260,000 NSW residents recruited 2005-2009
About: As part of the Australian Cancer Risk Study (led by CI Steinberg), genomic data were generated for >7,400 participants, including a randomly selected subset as well as participants diagnosed with prostate, breast, melanoma, and colorectal cancers.
GERA contact: CI Julia Steinberg
More information: https://www.saxinstitute.org.au/solutions/45-and-up-study/
Australian Melanoma Family Study (AMFS) Cohort. Population-based family study including 1,164 melanoma families recruited in Sydney, Melbourne and Brisbane
About: TBC
GERA contact: AI Mark Jenkins
More Information: PMID: 19887461
Breast Cancer Association Consortium (BCAC). Global collaboration of research institutions and sources that investigates the genetics of breast cancer.
About: The consortium includes over 100 study groups and data for over 400,000 individuals. The data include demographics, risk factors, and diagnosis, pathology, treatment and outcome of breast cancer patients, genomics, germline sequence data and tumour data.
GERA contact: CI Melissa Southey and Shuai Li
More Information: https://www.ccge.medschl.cam.ac.uk/breast-cancer-association-consortium-bcac
Breast Cancer in High-Risk Women. International collaboration that investigates the genetics of high-risk breast cancer
About: The study includes ~3,500 high-risk breast cancer patients and ~3,500 low-risk women without breast cancer, recruited by 17 studies in six countries. The data include demographics, breast cancer diagnosis and genomics.
GERA contact: CI Shuai Li and Enes Makalic
More Information:
Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Global collaboration of research institutions and sources that investigates the genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers.
About: The consortium includes over 85 study groups and data for over ~85,000 female and male BRCA1 and BRCA2 mutation carriers. The data include demographics, risk factors, and diagnosis, pathology, treatment and outcome of breast cancer patients, pedigree and genomics data.
GERA contact: CIs Melissa Southey and Shuai Li
More information: https://www.ccge.medschl.cam.ac.uk/consortium-investigators-modifiers-brca12-cimba
Colon Cancer Genomics Resource. A combination of genomic data from three international studies
About: The resource is a combination of genomic data from the Colon Cancer Family Registry (CCFR), the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), and the Colorectal Cancer Transdisciplinary Study (CORECT). There are ~50,000 colorectal cancer cases and ~60,000 individuals without colorectal cancer.
GERA contact: Al Mark Jenkins
More information:
Kathleen Cuningham Foundation Consortium for research into Familial Breast cancer (kConFab). Consortium of researchers from all over Australia and New Zealand and study resources that investigates the causes and consequences of familial predisposition to breast cancer
About: Started in 1997, kConFab has recruited over 2,300 families with a strong history of breast and breast/ovarian cancer. Genomic, germline mutation, epidemiological, medical and psychosocial data, and biospecimens have been collected from these families. The families have been followed up every 3 years since 2001 by the kConFab Clinical Follow-Up Project.
GERA contact: CIs Melissa Southey and Shuai Li
More information: https://www.kconfab.org/FollowUp
TwinLife is a 12-year representative study investigating the emergence and development of social inequalities over the life course
About: The long-term ongoing project began in 2014 and surveys more than 4,000 pairs of twins and their families in different stages of life on a yearly basis, including genetic data for some participants.
GERA contact: CI Lucas Calais-Ferreira
More information: https://paneldata.org/twinlife/
UK Biobank. A biobank study of ~500,000 individuals with various types of data collected
About: The UK Biobank recruited ~500,000 UK residents aged 40-69 years through 22 assessment centres in Scotland, England, and Wales during 2006-2010. All individuals received a baseline assessment at a centre to provide comprehensive information about their health and lifestyle, including touch screen questionnaires for detailed diet recall, face-to-face interviews with a study nurse, physical measurement, and sample collection of blood, urine and saliva. Imaging and multiple omics data have been collected.
GERA contact: AI Loic Yengo, CI Shuai Li, CI Julia Steinberg, AI Gillian Dite.
More information: https://www.ukbiobank.ac.uk/
Women’s Health Initiative (through dbGaP). The WHI’s aim is to improve health through research on risk factors, prevention, and early detection of serious health conditions, so that postmenopausal women thrive
About: The WHI enrolled more than 160,000 postmenopausal women aged 50–79 years and has over 15 years of follow-up. The WHI consists of three clinical trials and an observational study. The WHI is an ethnically and geographically diverse study of women in the United States.
GERA contact: AI Gillian Dite
More information:https://www.whi.org/ and https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000200.v12.p3